Ironing out Ferroportin.

نویسندگان

  • Hal Drakesmith
  • Elizabeta Nemeth
  • Tomas Ganz
چکیده

Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through the iron exporter ferroportin. The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin, and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense, and erythropoiesis. Fundamental questions about the structure and biology of ferroportin remain to be answered.

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عنوان ژورنال:
  • Cell metabolism

دوره 22 5  شماره 

صفحات  -

تاریخ انتشار 2015